Positive genetic interactions: high impact, but underrepresented in the literature

Genetic interactions reveal functional relationships between genes and are classified as negative or positive. Negative interactions typically link genes with similar functional annotations, while positive interactions are often viewed as less informative and typically link genes that are less obviously related. Integrating yeast genetic interaction data with literature and citation metrics, we find that positive interactions are consistently associated with higher scientific impact yet remain underrepresented in the literature.