Infection of ratites with clade 2.3.4.4b HPAIV H5N1: Potential implications for zoonotic risk

  1. Holly A. Coombes
  2. Jacob Terrey
  3. Audra-Lynne Schlachter
  4. Phoebe McCarter
  5. Isabella Regina
  6. Richard Hepple
  7. Natalie McGinn
  8. James Seekings
  9. Jayne Cooper
  10. Benjamin Clifton
  11. Benjamin C. Mollett
  12. Marco Falchieri
  13. Alejandro Nunez
  14. Scott M. Reid
  15. Joe James
  16. Ashley C. Banyard
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Abstract

We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.

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