Thiol-epoxy Click Chemistry: The Synthesis of Vicinal Amino Alcohols Containing 1,2,4-Triazole Ring

  1. Artyom V. Petrosyana
  2. Astghik A. Shahkhatuni
  3. Andranik M. Davinyan
  4. Karine S. Avetisyan
  5. Tariel V. Ghochikyan
  6. Melanya A. Samvelyan
  7. Valentine G. Nenajdenko
  8. Armen S. Galstyan
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Abstract

As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. According to as a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in 1-(oxiran-2-ylmethyl)piperidine has a catalytic (anchimer) effect.

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