Bioinformatics analyses and verification the promoting cancer role of RRM2 in cervical cancer

Background: Cervical cancer is one of the most common malignant tumours in women, and is the seventh highest among cancers, cervical cancer main caused by HPV infection; Xinjiang is a high incidence of cervical cancer. Immunotherapy is a new type of tumour therapy based on immune checkpoints, which has made a big breakthrough in the treatment of cancer. Ribonucleotide reductase subunit M2 (RRM2) is expressed at increased levels in cervical cancer and is associated with apoptosis and proliferation of cancer cells. In this study we explore the mechanism of RRM2 regulates the high expression of PD-L1 in cervical cancer through ERK signaling pathway by Bioinformatics analyses and experiments, and also investigate the role of RRM2 in cervical cancer . Methods: Bioinformatics analyses and experiments were carried out to revealed the promoting cancer role of RRM2 in cervical cancer and verify that RRM2 enhanced PD-L1 expression through activation of the ERK signaling pathway. Results: RRM2 plays an crucial role in the occurrence and progression of cervical cancer and enhanced the expression of PD-L1 in cancer cells via activating the ERK signaling pathway.