Single-molecule neuromorphic device

Artificial neural network-based machine learning provides foundations for artificial intelligence (AI), yet requires high energy costs for training. Beyond software-level simulation of neural networks, hardware-level implementation via neuromorphic devices becomes the next milestone in nanoscience towards energy-sustainable AI. Single-molecule devices have the potential for ultimate scale and energy efficiency, but challenges remain in achieving programmable multi-conductance states amidst room-temperature thermal fluctuations. Here we fabricate a bio-inspired single-molecule neuromorphic device consuming ~2.8 aJ/operation by electrochemically gating molecule-ion electrostatic interactions. This device realizes biomimetic emulation of neural plasticity from short-term to long-term memory featuring over 10 distinct conductance states, demonstrating the applications in Pavlovian conditioning for associative learning and pattern recognition in Morse code processing. Our approach enables multi-state synaptic emulation using an individual molecule toward energy-sustainable AI.