Transcriptomic Profiling of Muscle-Derived Stromal and Adipocytes Cells Exposed to Suborbital Microgravity

Spaceflight negatively impacts skeletal muscle mass and function, and current countermeasures fail to completely offset those alterations. Innovative approaches are then needed to understand the mechanisms governing space-induced muscle changes. This study explores short-term microgravity (suborbital flight) effects on transcriptional profile of skeletal muscle mesenchymal cells and intramuscular adipose tissue. We identified a set of molecular factors and biological processes impacted by microgravity in these cell types, warranting further investigation.