Global Scientometric Mapping of Research Linking the Enteric Nervous System and Oxidative Stress

Background and Aims The enteric nervous system (ENS) is a key regulator of gastrointestinal homeostasis and a recognized target of oxidative stress in inflammatory, metabolic, and neurodegenerative disorders. Despite growing experimental and clinical research, the scientific landscape linking the ENS and oxidative stress has not been systematically mapped. This study aimed to conduct a scientometric analysis of research at this interface. Methods Original research articles indexed in Web of Science, Scopus, and PubMed were retrieved using predefined search strategies and screened according to PRISMA guidelines. A total of 221 publications were included. Scientometric analyses assessed temporal trends, leading journals, authors and institutions, collaboration networks, keyword co-occurrence, and thematic evolution using bibliometric software. Results Scientific output increased steadily from 2001 onward, with pronounced growth after 2015. Publications were concentrated in neurogastroenterology and autonomic physiology journals, with a limited number of authors and institutions responsible for a substantial proportion of the literature. Keyword co-occurrence analysis identified five major thematic clusters related to inflammation, neurodegeneration, diabetic neuropathy, aging, and antioxidant mechanisms. Thematic mapping showed that oxidative stress and inflammation represent core research areas, whereas inflammatory bowel disease and metabolic disorders remain peripheral. International collaboration networks were limited. Conclusions Research linking the ENS and oxidative stress has expanded and matured over the past two decades, yet remains concentrated around a limited set of themes and collaborative hubs. The relative scarcity of integrative studies addressing metabolic and neurodegenerative diseases highlights critical gaps with translational relevance. Strengthening international collaborations and adopting interdisciplinary approaches may accelerate conceptual advances and promote clinical translation in neurogastroenterology.