Extraction of Mango (Mangifera indica) leaves and formulation of the extract as an antimicrobial dermal delivery system

This study aimed to develop and evaluate a topical polymeric patch of mangiferin-rich leaf extract for localized antimicrobial activity. Mangiferin liquid extract was obtained by Soxhlet extraction using methanol. Antimicrobial activity was evaluated against Staphylococcus aureus , Pseudomonas aeruginosa , and Candida albicans using the agar well diffusion method. Dermal delivery system were formulated using hydroxylpropyl methyl cellulose and polyvinyl pyrrolidone at different polymer ratios. The patches were characterized for mechanical properties, swelling behavior, drug diffusion, content uniformity, and surface pH. The extract showed notable antimicrobial activity, with inhibition zones comparable to standard antimicrobial agents. Among the formulations, the patch containing hydroxylpropyl methylcellulose to polyvinyl pyrrolidone at a 2:1 ratio demonstrated optimal physicochemical performance and drug release. These findings indicate that mangiferin liquid extract is an effective antimicrobial agent and can be successfully delivered via dermal delivery systems for potential topical treatment of microbial skin infections.