Structural and Functional Bioinformatics of Neurexin: A Step Towards Understanding Neurodevelopmental Disorders

Neurodevelopmental disorders represent one of the most prevalent challenges in today’s society with their origins often linked to critical process underlying nervous system development. The proteins that regulate these essential processes are vulnerable to mutations, which can disrupt normal function and contribute to the development of these disorders. Synaptogenesis, the formation of synapses, plays a pivotal role in neural development and functioning. Dysregulation of the genes responsible for proteins that facilitate synapse formation can lead to neurodevelopmental disorders. To explore the current understanding of this process and to refine research inquiries, a comprehensive literature review was conducted. Additionally, bioinformatical modeling was performed to understand the function of Neurexin, protein that plays important role in synapse formation process. Bioinformatical modeling included steps as determining 3D structure of protein, which is essential for understanding protein’s function, identifying proteins it interacts with and finally molecular docking with largest proteins it interacts with. Each of these proteins has the capacity of serving as potential target for drug development. Advancing our knowledge in this field holds promise for the development of improved therapeutic strategies for various neurological diseases and conditions. Continued investigation into synaptogenesis could significantly enhance treatment options and outcomes for affected individuals.