Biophysics
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Polyphosphate Discriminates Protein Conformational Ensembles More Efficiently than DNA Promoting Diverse Assembly and Maturation Behaviors
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PRC1 resists microtubule sliding in two distinct resistive modes due to variations in the separation between overlapping microtubules
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Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules
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Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes
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Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove
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Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion
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Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization
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Physical constraints and biological regulations underlie universal osmoresponses
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Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method
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Harnessing AlphaFold to reveal hERG channel conformational state secrets
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