Pharmacology and Toxicology
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Towardin vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia
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Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
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Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug ReducesToxoplasma gondiiBrain Cysts
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Application of thein vivooxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity
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Antifungal effects of PC945, a novel inhaled triazole, onCandida albicans-infected immunocompromised mice
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Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure
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Applications of Machine Learning in Decision Analysis for Dose Management for Dofetilide
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A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite
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Complex versus simple models: ion-channel cardiac toxicity prediction
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