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A list by Prachee Avasthi Recommended Reading
See what researchers at Prachee Avasthi’s lab are reading to discover some interesting new work.
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Formin tails act as a switch, inhibiting or enhancing processive actin elongation
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Synergistic action of actin binding proteins regulate actin network organization and cell shape
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Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves
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Regeneration of actin filament branches from the same Arp2/3 complex
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Synthetic control of actin polymerization and symmetry breaking in active protocells
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Universal length fluctuations of actin structures found in cells
This article's authorsAnnotation by Prachee Avasthi Recommended Reading
Length control of cytoskeletal filaments and superstructures is a really interesting area of study given maintenance of length is typical critical for polymer function. This new interesting model attempts to describe to actin filaments across various superstructures found in different cell/tissue types. Ultimately, a balance of assembly and disassembly can’t explain the observed length variance of filaments alone but considering crosslinked actin bundles (with filaments exponentially distributed within and defined by the length of the longest filament) can explain the observed variance relative to mean bundle length. There’s an interesting side prediction of the decay of bundle width as a function of distance from the assembly site which is consistent with observed width changes in yeast actin cables.
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Ciliary protein CEP290 regulates focal adhesion via microtubule system in non-ciliated cells1
This article's authorsAnnotation by Prachee Avasthi Recommended Reading
Cilia proteins often have extra ciliary roles but this is a particularly interesting result because the protein in question is CEP290, a protein whose function seems so localization dependent. It’s thought to comprise the Y-links that can be seen by electron microscopy to link the ciliary microtubule core to the ciliary membrane in a region known to gate what goes in and what stays out of the cilium (called the transition zone). Authors find here that there are extra ciliary roles in microtubule dynamics and cell adhesion for CEP290 in IMCD3 cells when they are cycling and don’t have cilia. It would be interesting to note any CEP290 functions in a cell that was truly cilium-incompetent like Jurkat T cells.
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Non-muscle myosin 2 filaments are processive in cells
This article's authorsAnnotation by Prachee Avasthi Recommended Reading
Really well written article showing for the first time that non-muscle myosin 2, largely thought to be contractile rather than processive, has the ability to move toward the leading edge of cells on parallel actin bundles (against retrograde actin flow).
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Evolution of the ribbon-like organization of the Golgi apparatus in animal cells
This article's authorsAnnotation by Prachee Avasthi Recommended Reading
This paper is a neat example of correlating cell level traits (ribbon-like Golgi) with protein evolution (interaction of Golgi architecture proteins predicted using alpha fold) to make hypotheses about the origin of cellular structures and associated functions
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Frequent sexual reproduction limits adaptation in outcrossed populations of the algaChlamydomonas reinhardtii
This article's authorsAnnotation by Prachee Avasthi Recommended Reading
Totally fascinating and surprising (to me) study suggesting more frequent mating in Chlamy results in worse rather than better adaptation to a challenging environment (high salt)